Synthesis and Characterization of 3-Substituted Indole Derivatives as Novel Mannich Bases
نویسندگان
چکیده
منابع مشابه
synthesis and characterization of some macrocyclic schiff bases
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15 صفحه اولDesign, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents
A series of benzamide substituted Mannich bases (1-7) were synthesized. The synthesized derivatives were authenticated by TLC, UV-Visible, FTIR, NMR, and mass spectroscopic techniques and further screened for in vitro antibacterial activity by test tube dilution method using amoxicillin and cefixime as standard drugs. The compounds 5, 6, and 7 were found to be the most active antibacterial agen...
متن کاملSYNTHESIS OF PARACETAMOL DERIVATIVES AS MANNICH BASES AND THEIR ANTIBACTERIAL ACTIVITY
Aim: A variety of Paracetamol derivatives as mannich bases were prepared through mannich reaction by reacting Paracetamol as compound containing active hydrogen, substituted benzaldehyde, morpholine as secondary amine compound and small amount of conc. HCl as catalyst. A simplistic one-pot method under mild conditions has been developed for the synthesis of all the compounds and they were chara...
متن کاملSynthesis and Evaluation of 1,3 Di-Substituted Schiff, Mannich Bases and Spiro Isatin Derivatives
Schiff bases of isatin with aminothiazole, its N-mannich bases and Spiro isatin derivatives were synthesized. Their chemical structures were confirmed by Infrared, 1H-Nuclear Magnetic Resonance data and elemental analysis. Antimicrobial evaluation was performed by the agar diffusion method against four pathogenic bacteria and two pathogenic fungi. Anti-inflammatory activity was tested by carrag...
متن کاملSynthesis, characterisation and evaluation of N-mannich bases of 2-substituted Benzimidazole derivatives.
RATIONALE Benzimidazoles and its derivatives represent one of the mainly biological active classes of literature. AIM In this present study aimed to synthesize N-mannich bases derivatives compounds bearing of 2-substituted benzimidazole moiety, in order to investigate their possible biological activity. METHOD Benzimidazole compounds were prepared from the condensation reaction between orth...
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ژورنال
عنوان ژورنال: Asian Journal of Chemistry
سال: 2021
ISSN: 0975-427X,0970-7077
DOI: 10.14233/ajchem.2021.23035